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Turbinamide, a new selective cytotoxic agent from the Mediterranean tunicate Sidnyum turbinatum
A Aiello1, S Carbonelli, G Esposito
1Dipartimento di Chimica delle Sostanze Naturali and Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131 Naples, Italy.
Organic Letters
|September 14, 2001
Abstract:
A unique cytotoxic metabolite, turbinamide (1), has been isolated from the marine tunicate Sidnyum turbinatum through a bioassay-guided approach. Its structure has been elucidated by an extensive spectroscopic analysis. Turbinamide demonstrated a strong and selective cytotoxic effect against neuronal cells rather than immune system cells. Structure: see text.