Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stupor from lamotrigine toxicity.

M Sbei1, J V Campellone

  • 1Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Epilepsia
|September 14, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral infarction during hypertensive encephalopathy: Case report with pathologic and atypical radiographic findings.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Effect of screening for syphilis on the management of patients with cerebrovascular disease.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Peroneal neuropathy from antithrombotic stockings.

Journal of clinical neuromuscular disease·2008
Same author

Clinical Approach to Neuromuscular Weakness in the Critically III Patient.

Journal of clinical neuromuscular disease·2008
Same author

A sensitive new median-ulnar technique for diagnosing mild Carpal Tunnel Syndrome.

Electromyography and clinical neurophysiology·2005
Same author

Age and the severity of carpal tunnel syndrome.

Electromyography and clinical neurophysiology·2004
Same journal

The Epilepsy-Cog study: Methods to establish a harmonized study of late onset epilepsy in a metacohort of six population-based cohorts in the United States.

Epilepsia·2026
Same journal

Systematic review and meta-analysis of lifestyle modification interventions and their impact on seizure reduction and quality of life.

Epilepsia·2026
Same journal

Vagus nerve stimulation for patients with tuberous sclerosis complex-related drug-resistant epilepsy: A prospective cohort study.

Epilepsia·2026
Same journal

Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video-electroencephalographic study.

Epilepsia·2026
Same journal

Perineuronal net abnormalities in epileptic human tissue.

Epilepsia·2026
Same journal

Cortical stimulation reveals effective disconnection of the epileptogenic network at seizure onset.

Epilepsia·2026
See all related articles

Acute lamotrigine (LTG) poisoning can cause severe encephalopathy. This condition is reversible upon LTG discontinuation, highlighting the importance of considering LTG toxicity in patients with altered mental status.

Area of Science:

  • Neuroscience
  • Clinical Toxicology
  • Pharmacology

Background:

  • Lamotrigine (LTG) is an anticonvulsant medication used to treat epilepsy and bipolar disorder.
  • Acute poisoning with LTG can occur following overdose.
  • Encephalopathy is a general term for brain dysfunction.

Observation:

  • A 55-year-year-old female presented with stupor after an overdose of lamotrigine (LTG) and valproic acid (VPA).
  • Laboratory evaluations revealed elevated serum LTG levels.
  • No other cause for the encephalopathy was identified.

Findings:

  • Discontinuation of LTG led to a complete recovery of neurological function.
  • The patient's mental status improved as serum LTG levels decreased.
  • This case suggests a potential causal link between LTG overdose and severe encephalopathy.

Related Experiment Videos

Implications:

  • Acute lamotrigine poisoning can induce severe, yet reversible, encephalopathy.
  • Clinicians should consider LTG toxicity in patients presenting with depressed mental status, especially those on LTG therapy.
  • This previously undescribed phenomenon expands the known spectrum of LTG toxicity.