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Renal transplantation with aged donors
T Nakatani1, T Kim, Y Takemoto
1Department of Urology, Osaka City University Medical School, Osaka, Japan. nakatani@msic.med.osaka-cu.ac.jp
Summary
Kidney transplants from older cadaveric donors, specifically non-heart-beating (NHB) donors, are associated with poorer renal function and lower graft survival rates compared to younger donors.
Area of Science:
- Nephrology
- Transplantation Immunology
- Geriatric Medicine
Background:
- Cadaveric kidney transplantation is a vital treatment for end-stage renal disease.
- The impact of donor age on outcomes of non-heart-beating (NHB) cadaveric renal transplantation remains unclear.
- Previous research suggests aged heart-beating donors increase risks in kidney transplantation.
Purpose of the Study:
- To investigate the influence of donor age on the outcomes of non-heart-beating (NHB) cadaveric renal transplantation.
- To compare renal function and graft survival rates between younger and aged donor groups.
Main Methods:
- A retrospective analysis of 63 patients who received cadaveric renal transplantation between July 1986 and May 1999.
- Patients were divided into two groups based on donor age: younger and aged donors.
- Comparison of nadir donor serum creatinine, immediate graft function, and graft survival rates.
Main Results:
- Aged donor group showed significantly worse mean nadir donor serum creatinine (P < 0.05).
- The aged donor group had a lower percentage of immediately functioning grafts and a higher percentage of non-functioning grafts.
- Graft survival rates were significantly lower in the aged donor group during the first 10 years post-transplant.
Conclusions:
- Cadaveric renal transplantation from NHB aged donors negatively impacts renal function and graft survival.
- Younger donors are associated with better outcomes in NHB cadaveric renal transplantation.
- Donor age is a critical factor to consider in NHB cadaveric kidney transplantation strategies.