Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treating diabetes with aerosolized insulin.

B L Laube1

  • 1Johns Hopkins University, Baltimore, MD, USA. blaube@welchlink.welch.jhu.edu

Chest
|September 14, 2001
PubMed
Summary

Aerosolized insulin offers a less painful alternative for diabetes management, showing similar glucose control to injections. Future devices aim to improve delivery efficiency for this novel inhaled therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What the pulmonary specialist should know about the new inhalation therapies.

The European respiratory journal·2011
Same author

Experimental and theoretical screening of nanoscale oxide reactivity with LiBH4.

Nanotechnology·2009
Same author

Early pulmonary response to allergen is attenuated during acute emotional stress in females with asthma.

The European respiratory journal·2003
Same author

A pilot study examining the relationship between stress and serum cortisol concentrations in women with asthma.

Respiratory medicine·2002
Same author

Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2001
Same author

Gene therapy in cystic fibrosis.

Chest·2001

Area of Science:

  • Endocrinology and Metabolism
  • Pharmaceutical Sciences
  • Respiratory Medicine

Background:

  • Diabetes mellitus treatment often involves daily insulin injections, leading to patient noncompliance due to pain and lifestyle disruption.
  • Aerosolized insulin formulations are being developed as a needle-free alternative to subcutaneous (SC) insulin delivery.
  • Improving patient adherence and treatment outcomes are key drivers for exploring inhaled insulin therapies.

Purpose of the Study:

  • To evaluate the efficacy and safety of aerosolized insulin as a potential replacement for injected insulin formulations.
  • To assess the pharmacokinetic and pharmacodynamic profiles of inhaled insulin compared to SC insulin.
  • To explore the potential of aerosolized insulin for managing both fasting and postprandial glucose levels in diabetic individuals.

Main Methods:

  • Human volunteer studies were conducted to assess aerosolized insulin delivery to the lung's alveolar region.
  • Comparative analysis of glucose-lowering effects and absorption rates between inhaled and SC insulin formulations.
  • Evaluation of pulmonary function, irritation, and hypoglycemia incidence during short-term administration of inhaled insulin.

Main Results:

  • Effective delivery of aerosolized insulin to the alveolar region resulted in absorption and glucose-lowering effects comparable to SC insulin during fasting states.
  • Inhaled insulin demonstrated efficacy in controlling postprandial glucose levels in human trials.
  • Short-term administration of aerosolized insulin was well-tolerated, with no evidence of respiratory irritation, hypoglycemia, or adverse pulmonary function changes.

Conclusions:

  • Aerosolized insulin presents a promising, less invasive alternative for diabetes mellitus management, potentially improving patient compliance.
  • While current delivery devices have limitations in efficiency, ongoing developments are expected to enhance administration compared to SC dosing.
  • Inhaled insulin serves as a model for the development of other peptide-based therapeutics currently requiring parenteral administration.

Related Experiment Videos