[Hepatoprotective effect of lipophen--a novel natural combined phospholipid preparation]

Studied in vitro, lipophen (in contrast to essentiale) did not separate the oxidation and phosphorylation processes in intact mitochondria. The antioxidant effect of lipophen with respect to enzymatic or ascorbate-dependent lipid peroxidation in intact microsomes from rat liver was higher by two-three orders of magnitude as compared to the effect of essentiale. In rats with a toxic hepatitis model induced by ethanol, lipophen restored the activity of mitochondria on a level characteristic of intact animals. In the case of CCl4-induced hepatitis, lipophen significantly increased the hydroxylase activity.