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Novel carbocyclic nucleosides containing a cyclobutyl ring: adenosine analogues
A R Hergueta1, F Fernandez, C López
1Departmento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago, Santiago de Compostela, Spain.
Chemical & Pharmaceutical Bulletin
|September 18, 2001
Abstract:
(1S,1'R)-cis-1-(3'-aminomethyl-2',2'-dimethylcyclobutyl)ethanol (1) and (1S,1'R)-cis-1-[3'-(2-aminoethyl)-2',2'-dimethylcyclobutyl]ethanol (2) were used as precursors in the synthesis of cyclobutyl nucleoside analogues containing adenine and 8-azaadenine moieties, which were tested as antiviral and antitumoral agents in a variety of assay systems. Compounds 8 and 9 displayed significant activity against respiratory syncytial virus, and compounds 14 and 15 were moderately active against vaccinia virus.