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Protein models in drug discovery
1Department of Structural Chemistry, Pharmacia Inc, Division Biovitrum, SE-11287 Stockholm, Sweden. martin.norin@biovitrum.com
Current Opinion in Drug Discovery & Development
|September 19, 2001
Summary
Protein structural information is now integral to drug discovery, from target identification to drug design. Combining structural data with combinatorial chemistry accelerates the development of novel therapeutics.
Area of Science:
- Biochemistry
- Structural Biology
- Medicinal Chemistry
Background:
- Protein structural information has become increasingly vital in modern drug discovery.
- Its application spans the entire drug development pipeline, including target identification and drug candidate design.
Purpose of the Study:
- To highlight the mature and widespread utilization of protein structural data in drug discovery.
- To emphasize the synergistic potential of combining structural information with combinatorial chemistry.
Main Methods:
- Leveraging genomics to identify and select drug targets.
- Employing structural genomics initiatives to generate 3-D protein structures.
- Integrating target structural information with combinatorial chemistry approaches.
Main Results:
- Protein structural information is now applied throughout the drug discovery process.
- Synergies between target structural data and combinatorial chemistry offer powerful methodologies.
- Structural genomics initiatives are rapidly producing novel 3-D molecular structures.
Conclusions:
- The integration of protein structural information significantly enhances rational drug design.
- Advancements in structural genomics provide a wealth of data for discovering new drug candidates.
- The combination of structural insights and chemical synthesis is a key driver in modern drug discovery.