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Related Experiment Videos

Blue Rubber Bleb Nevus Syndrome.

John M. Andersen1

  • 1Department of Pediatrics, Division of Pediatric Gastroenterology, University of Texas Southwestern Medical School, Children's Medical Center of Dallas, 1935 Motor Street,Dallas, TX 75235, USA. janderse@childmed.dallas.tx.us

Current Treatment Options in Gastroenterology
|September 19, 2001
PubMed
Summary

Blue rubber bleb nevus syndrome (BRBNS) causes gastrointestinal venous malformations leading to anemia. Aggressive management, including endoscopic ablation and surgery, is crucial for reducing blood loss and improving hemoglobin levels in BRBNS patients.

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Management of Esophageal Strictures in Children.

Current treatment options in gastroenterologyยท2003
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Area of Science:

  • Gastroenterology
  • Vascular Malformations
  • Hematology

Background:

  • Blue rubber bleb nevus syndrome (BRBNS) is characterized by venous malformations throughout the gastrointestinal tract.
  • These malformations frequently cause significant gastrointestinal blood loss and anemia, often necessitating gastroenterologist intervention.

Purpose of the Study:

  • To outline effective management strategies for gastrointestinal venous malformations in BRBNS.
  • To emphasize the need for aggressive treatment to control blood loss and normalize hemoglobin levels.

Main Methods:

  • Supportive therapies including proton pump inhibitors, octreotide, iron replacement, and blood transfusions.
  • Endoscopic ablation and surgical interventions, such as laparotomy, excision, surgically assisted enteroscopy, and thermal ablation via enterotomy.

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Main Results:

  • Aggressive, multi-modal treatment is required for effective management of BRBNS-related gastrointestinal venous malformations.
  • A collaborative approach between surgeons and therapeutic endoscopists is essential for treating both large and small lesions.

Conclusions:

  • Effective management of anemia in BRBNS hinges on aggressive treatment of small bowel venous malformations.
  • Currently, no systemic therapy effectively treats the underlying vascular malformations in BRBNS.