Peroxisome proliferator-activated receptors in endothelial cell biology

New insights into the endothelium as a dynamic, interactive organ have generated increased interest in endothelial cell transcriptional regulation. Peroxisomal proliferator-activated receptors (PPARs), as ligand-activated nuclear receptors expressed in endothelial cells, represent one important pathway that likely influences vascular responses both directly and indirectly by altering gene expression. PPAR ligands such as fibrates (PPAR-alpha) and insulin-sensitizing thiazolidinediones (PPAR-gamma) are in clinical use and may alter the process of atherosclerosis. The present review highlights the emerging evidence for PPAR-alpha and PPAR-gamma expression in the vasculature, as well as their potential roles in endothelial cell biology.