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Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenic Yersinia
J Hein1, A Sing, M S Di Genaro
1Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, Pettenkoferstrasse 9a, München, D-80336, Germany. joachim.hein@mikrobio.med.uni-erlagen.de
Microbial Pathogenesis
|September 20, 2001
Abstract:
Previous results have demonstrated an essential role of gamma interferon (IFN-gamma) in resistance against Yersinia enterocolitica. Hence, we investigated the course of Yersinia infection in mice deficient for the IFN-gamma-inducing cytokines interleukin-12 (IL-12 p40(-/-)) or interleukin-18 (IL-18(-/-)). The experiments described herein argue for a critical role of both cytokines in protective immune responses against this pathogen.