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Parallel DNA containing pyrazolo[3,4-D]pyrimidine analogues of isoguanine
1Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastr. 7, D-49076 Osnabrück, Germany.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
The phosphoramidites of 8-aza-7-deaza-2'-deoxyisoguanosine (1a) and its bromo derivative 1b as well as of 6-aza-2'-deoxyisocytidine and its 5-methyl derivative (3a,b) were synthesized. Parallel-stranded duplexes containing the nucleosides 1a,b show a significantly enhanced duplex stability compared to those containing 2'-deoxyisoguanosine.