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Specific binding and stabilization of DNA and phosphorothioate DNA by amphiphilic alpha-helical peptides
1Department of Chemistry, School of Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Synthetic cationic peptides with amphiphilic alpha-helical structure were found to have DNA binding ability to stabilize double and triple stranded DNA. The stabilization effect was significant for cationic alpha-helical peptides indicating the importance of an electrostatic interaction of a positive charge of peptides and a negative charge of DNAs.