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The synthesis of, and studies on, 2'-C-modified nucleotides
L Brennan1, K J Fettes, I A O'Neil
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
The synthesis of uridine monomers containing either a 2'-deoxy-2'-C-methylcyano or ethylcyano group is described. These monomers are intended for incorporation into oligonucleotides to investigate a proposed duplex-stabilising effect exerted by 2'-tethered amide groups.