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Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: improvement by
B Schneider1, P Meyer, S Sarfati
1Unité de Régulation Enzymatique des Activités Cellulaires, CNRS URA 1773, Institut Pasteur, Paris, France.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH3-) or a thio (SH) group on the alpha-phosphate. Both the alpha-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of alpha-borano nonophosphate derivatives in terminated viral DNA chain.