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Isonucleosides incorporating universal bases
1Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Enantiomeric isodideoxynucleosides of the (S,S) and (R,R) families with the universal base, imidazole-4-carboxamide as the nucleobase, were synthesized as biological mimics of anti-HIV active D- and L-related isodideo-xyadenosines. In vitro anti-HIV evaluation in CEM cells of these target compounds showed that they were inactive. Further antiviral studies are in progress.