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2'-O-modified oligoribonucleotides with terminal 3'-3'-internucleotide linkage and their derivatives
D Novopashina1, M Kuznetsova, A Venyaminova
1Novosibirsk State University, ul. Pirogova 2, Novosibirsk 630090, Russia.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
A high RNA binding affinity and nuclease resistance of 2'-O-modified (2'-O-methyl, 2'-O-tetrahydropyranyl) oligoribonucleotides containing the "inverted" T at the 3'-end have been shown. The synthesis and properties of new photoactivatable perfluoroarylazide derivatives of these oligoribonucleotides are discussed.