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Related Experiment Videos

Gamma glutamyl transferase.

J B Whitfield1

  • 1Department of Clinical Biochemistry, Royal Prince Alfred Hospital, and University of Sydney, NSW, Australia. johnwhit@bioc.rpa.cs.nsw.gov.au

Critical Reviews in Clinical Laboratory Sciences
|September 21, 2001
PubMed
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Serum gamma-glutamyl transferase (GGT) is a marker for liver dysfunction and alcohol intake. Elevated GGT levels are linked to increased oxidative stress and higher risks of heart disease, diabetes, stroke, and mortality.

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Epidemiology

Background:

  • Serum gamma-glutamyl transferase (GGT) is a well-established biomarker for liver dysfunction and alcohol consumption.
  • Recent research has elucidated GGT's physiological role in managing oxidative stress via glutathione metabolism.
  • GGT's involvement in oxidative stress and its association with various health conditions are areas of active investigation.

Purpose of the Study:

  • To review the clinical applications of serum GGT.
  • To present current understanding of GGT's physiological functions.
  • To integrate findings from epidemiological studies with GGT's clinical and physiological roles.

Main Methods:

  • Literature review of clinical applications and physiological roles of GGT.

Related Experiment Videos

  • Analysis of epidemiological studies investigating GGT associations with disease risk.
  • Synthesis of existing knowledge to form an integrated view of GGT.

    • Main Results:

    • Serum GGT serves as an index for liver dysfunction and alcohol intake.
    • GGT plays a role in counteracting oxidative stress, but its reaction products can also increase free radical production.
    • Elevated GGT is independently associated with increased risk of coronary heart disease, Type 2 diabetes, stroke, and overall mortality.

    Conclusions:

    • Serum GGT has diverse clinical applications beyond liver function and alcohol markers.
    • Understanding GGT's physiological role in oxidative stress is crucial.
    • GGT is a significant independent predictor of cardiovascular diseases, diabetes, stroke, and mortality, necessitating an integrated clinical and research perspective.