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Risk factors of oesophagitis in arthritic patients
B Avidan1, A Sonnenberg, T G Schnell
1Gastroenterology Section, The Department of Veterans Affairs Medical Center, 1501 San Pedro Drive SE, Albuquerque, New Mexico 87108, USA.
European Journal of Gastroenterology & Hepatology
|September 21, 2001
Summary
Nonsteroidal anti-inflammatory drug (NSAID) users frequently develop erosive esophagitis. Young age, hiatus hernia, and heartburn are key risk factors, not peptic ulcers.
Area of Science:
- Gastroenterology
- Rheumatology
- Pharmacology
Background:
- Continuous nonsteroidal anti-inflammatory drug (NSAID) therapy is common for rheumatological conditions.
- The specific risk factors for esophageal mucosal injury in NSAID users remain unclear.
Purpose of the Study:
- To identify risk factors for erosive esophagitis in patients on chronic NSAID therapy.
- To investigate the relationship between NSAID use, gastrointestinal symptoms, and esophageal damage.
Main Methods:
- A prospective case-control study involving outpatients regularly consuming NSAIDs for osteoarthritis.
- Data collection included structured interviews and upper gastrointestinal endoscopy.
Main Results:
- 21% of NSAID users developed esophagitis; gastric/duodenal ulcers did not predict esophageal damage.
- Younger age (OR 1.79/decade), hiatus hernia (OR 3.72), and heartburn (OR 4.78) significantly increased esophagitis risk.
- Alcohol, nicotine, and NSAID type were not associated with increased risk.
Conclusions:
- Erosive esophagitis is common in patients on chronic NSAID therapy for rheumatological diseases.
- Risk is elevated in those with pre-existing gastro-esophageal reflux tendencies; NSAID-induced peptic ulcer disease does not increase this risk.
- Heartburn is a critical symptom warranting consideration for erosive esophagitis in NSAID users.
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