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Updated: Oct 4, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
Improved low-energy electron injection systems for high rate electron capture dissociation in Fourier transform ion
Y O Tsybin1, P Håkansson, B A Budnik
1Ion Physics Division, Angström Laboratory, Uppsala University, Box 534, SE-751 21 Uppsala, Sweden.
Abstract:
New low-energy electron injection systems based on indirectly heated dispenser cathodes facilitate electron capture dissociation (ECD) in Fourier transform ion cyclotron resonance (FTICR) mass spectrometry. In this joint report, details are presented of the design and performance of these systems on two commercial FTICR instruments, 9.4 T Bruker BioAPEX in Uppsala and 4.7 T IonSpec Ultima in Odense. New results include obtaining meaningful one-scan MS/MS data for isolated precursor ions with millisecond irradiation times. The ECD rate improvement is not only due to the larger total electron current, but the larger emitting area as well.
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