[Pharmacological activity of immunomodulators in adjuvant arthritis]

Clinical features and functional activity of T- and B-cells were studied on the model of adjuvant arthritis which is the disease associated with activation of B-cells after monotherapy of rats with IM-1 (B-cell stimulator), dibazol (T-cell stimulator), alpha-tocopherol acetate (cintrol). It was established that B cells are most sensitive to the stimulation while T-cell reaction to the stimulators in disease is inhibited. Therefore, at early stages of arthritis and, probably, in other inflammatory diseases of autoimmune origin, stimulators of B-cells can be used for prophylaxis and treatment while at late stages--stimulators of T-cells.