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[Effect of perftoran on experimental hepatitis]
A Iu Kovelenov1, Iu V Lobzin, N N Pluzhnikova
1Department of Infectious Diseases, St. Petersburg State Military Medical Academy, Ministry of Defense of the Russian Federation, ul. Lesoparkovaya 4, St. Petersburg, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|September 22, 2001
Summary
Perftoran accelerates recovery from experimental hepatitis in rats by reducing liver lipid peroxidation. This drug modulates key enzymes, enhancing the liver
Area of Science:
- Hepatology
- Biochemistry
- Pharmacology
Background:
- Experimental acute hepatitis models were established using allyl alcohol or P. acnes with typhoid endotoxin.
- Hepatitis is characterized by liver damage and inflammation.
Purpose of the Study:
- To investigate the therapeutic effects of perftoran on experimental acute hepatitis in albino rats.
- To elucidate the mechanisms underlying perftoran's action on liver injury.
Main Methods:
- Administration of perftoran (10 ml/kg) to rats with induced hepatitis.
- Assessment of cytolytic syndrome elimination and lipid peroxidation levels.
- Enzyme activity assays for prooxidant and antioxidant factors in liver tissue.
Main Results:
- Perftoran administration led to faster resolution of the cytolytic syndrome.
- The drug significantly affected lipid peroxidation in the rat liver.
- Perftoran inhibited xanthine oxidase and Kupffer cell myeloperoxidase.
- It also induced the synthesis of hepatocyte antiperoxidation factors: catalase, glucose-6-phosphate dehydrogenase, and reduced glutathione.
Conclusions:
- Perftoran demonstrates a protective effect against experimental acute hepatitis in rats.
- Its mechanism involves the modulation of lipid peroxidation and antioxidant defense systems in the liver.