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Vasa homolog genes in mammalian germ cell development
T Noce1, S Okamoto-Ito, N Tsunekawa
1Laboratory of Reproductive Biology, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan. noce@libra.ls.m-kagaku.co.jp
Cell Structure and Function
|September 22, 2001
Abstract:
Many vasa homologue genes to Drosophila vasa have been isolated in various animal species. They provide specific molecular probes to analyze the establishment and the differentiation of germ cell lineage. In mammals, the expression of VASA protein becomes detectable in PGCs at the late migrating stage. Interestingly, during spermatogenesis the intracellular localization of VASA protein is closely associated with the chromatoid body.