Dynamic sonography of hepatic tumors.
1Department of Cancer Survey, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3, Nakamichi, Higashinari, Osaka, 537-8511 Japan.
AJR. American Journal of Roentgenology
|September 22, 2001
Summary
Dynamic sonography effectively characterizes liver tumors using pulse inversion harmonic imaging and contrast agents. This advanced ultrasound technique accurately differentiates between malignant and benign hepatic lesions, improving diagnostic capabilities.
Area of Science:
- Medical Imaging
- Hepatology
- Oncology
Background:
- Conventional sonography can detect focal liver lesions but often requires further characterization.
- Accurate differentiation of hepatic tumors is crucial for appropriate patient management and treatment planning.
Purpose of the Study:
- To propose and evaluate a dynamic sonography protocol for characterizing hepatic tumors.
- To assess the diagnostic performance of this novel protocol.
Main Methods:
- A dynamic sonography protocol was developed using pulse inversion harmonic imaging and a galactose-based contrast agent (Levovist).
- The protocol involved bolus injection of the contrast agent to obtain vascular-phase and liver-parenchymal-phase images in 107 patients with focal liver lesions.
Main Results:
- Dynamic sonography demonstrated high sensitivity and specificity for diagnosing hepatocellular carcinoma (92%, 96%), cholangiocarcinoma/metastasis (90%, 95%), and hemangioma (60%, 100%).
- Specific enhancement patterns (e.g., mosaic, ring, puddle) correlated with tumor types.
- Benign lesions like hemangiomas and focal fat-spared regions showed no focal sign in the liver parenchymal phase.
Conclusions:
- Dynamic sonography, combining pulse inversion harmonic imaging and contrast agent injection, is an effective tool for liver tumor characterization.
- This protocol enhances diagnostic accuracy for various hepatic lesions.
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