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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Tracheal invasion by thyroid carcinoma: prediction using MR imaging.
J C Wang1, S Takashima, F Takayama
1Department of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
AJR. American Journal of Roentgenology
|September 22, 2001
Summary
Magnetic resonance (MR) imaging accurately predicts tracheal invasion by thyroid carcinoma. Combining specific MR imaging findings, including intraluminal mass and tumor circumference, offers the highest diagnostic accuracy.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Thyroid carcinomas can invade adjacent structures, including the trachea.
- Accurate preoperative assessment of tracheal invasion is crucial for treatment planning.
Purpose of the Study:
- To evaluate the accuracy of MR imaging in predicting tracheal invasion by thyroid carcinomas.
- To establish MR imaging criteria for diagnosing tracheal invasion.
Main Methods:
- MR imaging was performed on cadavers and healthy subjects for reference.
- MR imaging findings in 67 patients with thyroid carcinoma were correlated with surgical and pathologic results.
- Logistic regression analysis identified significant MR imaging features for predicting tracheal invasion.
Main Results:
- Tracheal invasion was present in 34% of patients.
- Significant MR imaging predictors included soft-tissue signal in tracheal cartilage, intraluminal mass, and tumor circumference.
- A combination of these findings achieved 90% accuracy in diagnosing tracheal invasion.
Conclusions:
- MR imaging is an accurate modality for diagnosing tracheal invasion by thyroid carcinomas.
- A combination of MR imaging criteria provides the most reliable prediction of tracheal invasion.
