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The WHO Vaccine Trial Registry.

S E Robertson1, M V Mayans, A El-Husseiny

  • 1Department of Vaccines and Biologicals, World Health Organization, CH-1211 27, Geneva, Switzerland. robertsons@who.int

Vaccine
|September 25, 2001
PubMed
Summary

The WHO Vaccine Trial Registry tracks global vaccine research, showing significant growth in clinical studies, especially in developing nations. This registry covers diverse infectious diseases, highlighting expanding vaccine development efforts worldwide.

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Area of Science:

  • * Global health
  • * Infectious disease research
  • * Clinical trials

Background:

  • * The World Health Organization (WHO) Vaccine Trial Registry prospectively collects data on clinical vaccine studies.
  • * The registry aims to document and track vaccine research activities globally.

Purpose of the Study:

  • * To provide an overview of vaccine clinical trials registered with the WHO.
  • * To assess the growth of vaccine research capacity, particularly in developing countries.
  • * To identify the range of infectious agents targeted by vaccine research.

Main Methods:

  • * Prospective registration of clinical vaccine studies supported by WHO.
  • * Data compilation and analysis of registered studies up to December 1999.
  • * Categorization of studies by country, infectious organism, and research trends over time.

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Main Results:

  • * As of December 1999, 103 vaccine studies from 43 countries were registered.
  • * Approximately 80% of these studies were conducted in developing countries.
  • * A notable increase in new studies per year was observed between 1987-1993 and 1994-2000.
  • * Registered studies addressed a wide array of infectious agents, including bacteria and viruses.

Conclusions:

  • * The WHO Vaccine Trial Registry demonstrates a growing global capacity for vaccine research and development.
  • * The registry highlights a strong focus on infectious diseases prevalent in developing nations.
  • * The data indicates an accelerating trend in clinical vaccine research over the late 20th century.