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Related Experiment Videos

Plasma selenium in specific and non-specific forms.

R F Burk1, K E Hill, A K Motley

  • 1Division of Gastroenterology, Department of Medicine and Clinical Nutrition Research Unit, Vanderbilt University School of Medicine, Nashville, TN 37221, USA. raymond.burk@mcmail.vanderbilt.edu

Biofactors (Oxford, England)
|September 25, 2001
PubMed
Summary
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Selenium

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Trace Element Metabolism

Background:

  • Selenium exists in plasma and tissues in both specific and non-specific forms.
  • Understanding the factors influencing these forms is crucial for human health.
  • Dietary selenium intake significantly impacts its metabolic pathways.

Purpose of the Study:

  • To investigate how different selenium compounds affect its distribution in human plasma.
  • To differentiate the metabolic fate of selenomethionine versus selenate in the body.
  • To determine the incorporation patterns of selenium into plasma proteins.

Main Methods:

  • Administered 400 µg of selenium daily for 28 days to a human subject, using either selenomethionine or selenate.
  • Measured plasma and albumin selenium concentrations.

Related Experiment Videos

  • Analyzed the molar ratio of methionine to selenium in albumin.
  • Studied selenocysteine incorporation into albumin in rats using (75)Se-selenocysteine.

    • Main Results:

    • Selenomethionine supplementation increased plasma and albumin selenium concentrations.
    • Selenate supplementation did not significantly alter plasma or albumin selenium levels.
    • Selenium from selenomethionine was incorporated into albumin, indicated by a decreased methionine:selenium ratio.
    • No evidence of non-specific incorporation of selenocysteine into albumin was found.

    Conclusions:

    • Selenomethionine is incorporated into albumin, suggesting it utilizes the methionine metabolic pathway.
    • Selenate and selenocysteine do not appear to be non-specifically incorporated into plasma proteins.
    • These findings support selenomethionine as a non-specific selenium form, metabolized within the methionine pool, distinct from specific selenium metabolic processes.