Related Experiment Video
Updated: Aug 14, 2026

Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)
Published on: October 8, 2009
[The antiphospholipid syndrome and antiphospholipid antibodies]
1Ustav klinické imunologie a alergologie 1. LF UK a VFN, Praha. kmali@lf1.cuni.cz
Abstract:
Antiphospholipid syndrome is a rate systemic autoimmune disease characterized by widespread arterial and venous thrombosis, recurrent abortion and thrombocytopenia. Laboratory tests reveal antibodies against phospholipids. These antibodies are detected by functional tests for the lupus anticoagulant, the anticardiolipin ELISA, the anti-beta 2-glycoprotein 1 ELISA and ELISA tests for antibodies against other cofactors and phospholipids. Pathogenetic mechanisms of thrombosis are poorly understood. Diagnostic assays for detection of antiphospholipid have not been yet adequately standardized.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Hypersensitivity Reactions: Cytolytic Reactions
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Peripheral Artery Disease I: Introduction

