Impact of genomics in drug discovery

An ultra scale-down analysis of the recovery by dead-end centrifugation of human cells for therapy.

Biotechnology and bioengineering·2014

Use of adenovirus as a model system to illustrate a simple method using standard equipment and inexpensive excipients to remove live virus dependence on the cold-chain.

Vaccine·2014

CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).

Journal of clinical pharmacy and therapeutics·2011

The micromass test: Is it subject to strain variation?

Toxicology in vitro : an international journal published in association with BIBRA·2010

The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use.

Journal of clinical pharmacy and therapeutics·2007

A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis.

Allergy·2007

A refined qPCR duplexing method for the molecular sex determination of sturgeon (Acipenser genus), providing a validating, endogenous control.

BioTechniques·2026

A QC-guided framework for performance assessment in plate-based RNAi screening with fluorescence and metabolic readouts.

BioTechniques·2026

Detection of antisense oligonucleotides from biological samples by ligase detection reaction using T4 RNA ligase 2.

BioTechniques·2026

A PCR method to detect the mouse major histocompatibility complex H2-Ld gene that confers resistance to Toxoplasma encephalitis.

BioTechniques·2026

Investigating the interactomic landscape of survival motor neuron (SMN) and the SMNΔ7 truncated protein.

BioTechniques·2026

Antigen retrieval-immunofluorescence on free floating sections to visualize the liver lobule and its cellular makeup.

BioTechniques·2026

Spatial isoform sequencing at single-cell resolution reveals cell-type-specific spatial isoform variability in multiple brain cell types.

Nature methods·2026

Large-scale single-molecule analysis of tau proteoforms.

Nature methods·2026

Gene-Chronos: parameter-efficient developmental time inference using a pretrained single-cell foundation model.

Briefings in bioinformatics·2026

Improving long-read somatic structural variant calling with pangenome and de novo personal genome assembly.

Cancer research communications·2026

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment.

Science advances·2026

Upscaling Genotyping by Amplicon Sequencing With GBAS-GUI.

Molecular ecology resources·2026

Related Experiment Videos

Impact of genomics in drug discovery

Related Concept Videos

An ultra scale-down analysis of the recovery by dead-end centrifugation of human cells for therapy.

Use of adenovirus as a model system to illustrate a simple method using standard equipment and inexpensive excipients to remove live virus dependence on the cold-chain.

CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).

The micromass test: Is it subject to strain variation?

The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use.

A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis.

A refined qPCR duplexing method for the molecular sex determination of sturgeon (Acipenser genus), providing a validating, endogenous control.

A QC-guided framework for performance assessment in plate-based RNAi screening with fluorescence and metabolic readouts.

Detection of antisense oligonucleotides from biological samples by ligase detection reaction using T4 RNA ligase 2.

A PCR method to detect the mouse major histocompatibility complex H2-Ld gene that confers resistance to Toxoplasma encephalitis.

Investigating the interactomic landscape of survival motor neuron (SMN) and the SMNΔ7 truncated protein.

Antigen retrieval-immunofluorescence on free floating sections to visualize the liver lobule and its cellular makeup.

Spatial isoform sequencing at single-cell resolution reveals cell-type-specific spatial isoform variability in multiple brain cell types.

Large-scale single-molecule analysis of tau proteoforms.

Gene-Chronos: parameter-efficient developmental time inference using a pretrained single-cell foundation model.

Improving long-read somatic structural variant calling with pangenome and de novo personal genome assembly.

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment.

Upscaling Genotyping by Amplicon Sequencing With GBAS-GUI.

Related Experiment Videos

Impact of genomics in drug discovery

Related Concept Videos

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