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Related Experiment Videos

Blepharoclonus, pseudoasterixis, and restless feet.

D E Jacome1

  • 1Department of Medicine, Franklin Medical Center, Greenfield, Massachusetts, USA. dj@crocker.com

The American Journal of the Medical Sciences
|September 26, 2001
PubMed
Summary

This study identifies a new syndrome linking headaches, involuntary movements like blepharoclonus and pseudoasterixis, and peripheral neuropathy in 30 patients. Further research is needed to understand the cause of this complex neurological condition.

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Area of Science:

  • Neurology
  • Movement Disorders
  • Headache Medicine

Background:

  • A distinct syndrome involving headache, eyelid myoclonic tremors (blepharoclonus), wrist tremors mimicking asterixis (pseudoasterixis), and foot movements was observed in 30 patients.
  • Ten patients were detailed, showcasing a range of neurological symptoms and headache types.

Purpose of the Study:

  • To describe a novel syndrome characterized by specific involuntary movement disorders and headache.
  • To investigate potential associations between these neurological symptoms and underlying conditions.

Main Methods:

  • Clinical history and neurological examinations were performed.
  • Brain imaging (CT, MRI), EEG, EMG, and nerve conduction studies were utilized.
  • Headaches were classified using the International Headache Society criteria; a retrospective case review was conducted.

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Main Results:

  • The patient cohort presented with various headache types, including migraine and tension headache.
  • No brain tumors or vascular malformations were detected.
  • Associated conditions included somnambulism (in 8 patients), restless legs syndrome (in 8 patients), and evidence of axonal peripheral neuropathy (in 13 patients).

Conclusions:

  • This study suggests a potential link between headache, involuntary movement disorders, and peripheral neuropathy.
  • Further investigation is required to determine the underlying pathogenesis of this newly described syndrome.