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Extraskeletal Ewing sarcoma in a 77-year-old woman
C C Cheung1, R A Kandel, R S Bell
1Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Archives of Pathology & Laboratory Medicine
|September 26, 2001
Summary
Extraskeletal Ewing sarcoma (EES), a rare soft tissue tumor, can occur in older adults. This case highlights EES in a 77-year-old woman, emphasizing its occurrence beyond typical pediatric demographics.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Extraskeletal Ewing sarcoma (EES) is a rare soft tissue neoplasm.
- EES shares morphological similarities with bone Ewing sarcoma.
- It typically affects younger individuals, but adult cases are documented.
Observation:
- A case of EES in the left inguinal region of a 77-year-old woman is presented.
- The tumor was differentiated from other small, blue round cell tumors (SBRCTs) through extensive immunohistochemical marker analysis.
- Neural differentiation markers were absent, excluding primitive neuroectodermal tumor (PNET).
Findings:
- Histologic, histochemical, immunohistochemical, and electron microscopy analyses confirmed EES.
- The characteristic t(11;22)(q24;q12) fusion transcript was identified via reverse transcriptase-polymerase chain reaction (RT-PCR).
- Diagnostic confirmation involved a multi-modal approach including molecular genetics.
Implications:
- This case underscores that EES can occur in elderly patients, challenging the perception of it being exclusively a pediatric or young adult disease.
- Accurate diagnosis of EES requires a comprehensive evaluation, including molecular diagnostics, to distinguish it from other SBRCTs.
- Awareness of EES in older populations is crucial for appropriate clinical management and treatment strategies.
