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Related Experiment Videos

Remifentanil.

J Cohen1, D Royston

  • 1Department of Anesthesia, Royal Brompton and Harefield National Health Service Trust, Harefield Hospital, Middlesex, UB9 6JH, UK.

Current Opinion in Critical Care
|September 26, 2001
PubMed
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Remifentanil, an opioid, offers predictable effects due to rapid metabolism. Its unique profile makes it valuable in critical care, particularly for neurosurgical and cardiac surgery patients, enabling faster clinical assessments and recovery.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Remifentanil is an ultra-short-acting opioid analgesic.
  • It possesses a unique pharmacokinetic profile characterized by rapid and predictable clearance.
  • Metabolism occurs via nonspecific esterases, independent of organ function.

Purpose of the Study:

  • To review the distinct features of remifentanil compared to other opioids.
  • To outline the potential applications and benefits of remifentanil in critical care settings.
  • To highlight its utility in specific surgical intensive care unit (ICU) environments.

Main Methods:

  • Literature review of studies involving remifentanil.
  • Focus on its use in neurosurgical and cardiothoracic intensive care units.

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  • Analysis of pharmacokinetic data and clinical outcomes.

    • Main Results:

    • Remifentanil's predictable onset and offset facilitate rapid patient emergence for clinical evaluation.
    • It effectively manages intracranial pressure during neurosurgical procedures.
    • Provides excellent hemodynamic control in cardiac surgery and allows early return of spontaneous ventilation.
    • Potential to reduce postoperative intensive care unit (ICU) length of stay, especially after hepatic transplantation.

    Conclusions:

    • Remifentanil's pharmacokinetic advantages offer significant benefits in critical care.
    • Its use is particularly advantageous in neurosurgical and cardiac surgery ICUs.
    • Further investigation may support its role in optimizing patient recovery and resource utilization post-transplantation.