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Multinational collaborations in critical care research: feasible and useful?
Jorge I F Salluh1,2, Luigi Pisani3,1, Giulliana M Moralez1
1D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil.
Current Opinion in Critical Care
|June 19, 2026
Summary
Multinational research collaborations are vital for critical care evidence. Evolving infrastructure and methods support rigorous, representative studies, but sustained investment is key for global improvements.
Area of Science:
- Critical care medicine
- Health services research
- Global health equity
Background:
- Multinational research is essential for evidence-based critical care across diverse healthcare systems.
- Existing research models face challenges in representation and feasibility.
Purpose of the Study:
- To review multinational research models in critical care.
- To evaluate their feasibility, scientific value, and methodological innovations.
Main Methods:
- Review of registry-based studies, society-led networks, and south-south collaborations.
- Analysis of methodological innovations like federated analysis and target trial emulation.
- Examination of landmark studies and their collaborative approaches.
Main Results:
- Multinational ICU registries support observational studies and trials.
- Federated analysis and target trial emulation are promising for registry data.
- Society-led networks and south-south collaborations demonstrate feasibility and advance equity.
Conclusions:
- Multinational collaboration is a primary source of scientific evidence in critical care.
- Current infrastructure and methods support rigorous, representative, and relevant research.
- Sustained investment in registries, partnerships, and capacity-building is crucial for global impact.
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