Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rodent obesity models: an overview.

M Tschöp1, M L Heiman

  • 1Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, Indiana 46285, USA. tschoep@gmx.de

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|September 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Influence of hypobaric hypoxia on leptin levels in men.

International journal of obesity (2005)·2024
Same author

Diabetes Type 2 Treatments.

Drug research·2016
Same author

[Not Available].

Schmerz (Berlin, Germany)·2016
Same author

Ghrelin modulates encoding-related brain function without enhancing memory formation in humans.

NeuroImage·2016
Same author

Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.

Journal of neuroendocrinology·2015
Same author

Ghrelin.

Molecular metabolism·2015
Same journal

Association of Fibroblast Growth Factor 21 with Excessive Intrapancreatic Fat Deposition in Type 2 Diabetes Mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same journal

Mild cognitive impairment in newly diagnosed type 2 diabetes without microvascular or macrovascular complications: Prevalence, dynamics, and clinical predictors.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same journal

Cardiovascular Disease Risk Knowledge and Lifestyle Behaviors Among Adults With Metabolic Syndrome: A Cross Sectional Study.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same journal

Comparative Efficacy of Oral Antidiabetic Drugs on Metabolic Dysfunction-Associated Steatotic Liver Disease (MΑSLD) Progression in Type 2 Diabetes: A Retrospective Cohort Study.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same journal

Nutritional Recommendations for the Prevention of Type 2 Diabetes Mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same journal

Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score and Diabetic Neuropathy in Patients with Type 2 Diabetes Mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
See all related articles

This review covers various animal obesity models, including diet-induced, spontaneous, genetically engineered, and surgically altered rodents. It highlights the specific utility of each model for obesity research.

Area of Science:

  • Obesity research
  • Animal models
  • Metabolic disease

Background:

  • Animal models are crucial for understanding obesity.
  • Existing models vary significantly in type and induced obesity extent.
  • No single model perfectly recapitulates human obesity.

Purpose of the Study:

  • To review available rodent models for studying obesity.
  • To identify the greatest utility of each model.
  • To aid researchers in selecting appropriate models.

Main Methods:

  • Literature review of rodent obesity models.
  • Categorization based on induction method: environmental, spontaneous, genetic, mechanical.
  • Analysis of model characteristics and applications.

Related Experiment Videos

Main Results:

  • Diet-induced obesity models offer control over environmental factors.
  • Spontaneous mutant models (e.g., ob/ob mice) provide insights into genetic factors.
  • Genetically engineered models (e.g., MC4R knock-out) allow targeted gene function studies.
  • Mechanical intervention models (e.g., hypothalamic lesions) explore neurobiological pathways.

Conclusions:

  • Each rodent obesity model has unique strengths and limitations.
  • Model selection should align with specific research questions.
  • A comprehensive understanding of available models enhances research efficiency and validity.