Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retrograde signaling at central synapses.

H W Tao1, M Poo

  • 1Department of Molecular and Cellular Biology, University of California, Berkeley, CA 97420, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 27, 2001
PubMed
Summary

Retrograde signaling from target cells to neurons is crucial for synapse development and plasticity. Activity-dependent signals modify neuronal function, impacting information processing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sparse Labeling and Neural Tracing in Brain Circuits by STARS Strategy: Revealing Morphological Development of Type II Spiral Ganglion Neurons.

Cerebral cortex (New York, N.Y. : 1991)·2018
Same author

Emergence of input specificity of ltp during development of retinotectal connections in vivo.

Neuron·2001
Same author

GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition.

Cell·2001
Same author

Synaptic modification by correlated activity: Hebb's postulate revisited.

Annual review of neuroscience·2001
Same author

Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation.

Science (New York, N.Y.)·2001
Same author

Filopodial calcium transients promote substrate-dependent growth cone turning.

Science (New York, N.Y.)·2001

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Synaptic Plasticity

Background:

  • Transcellular retrograde signaling is essential for synaptic development, maturation, and plasticity.
  • This signaling occurs from postsynaptic target cells to presynaptic neurons.
  • Understanding these signals is key to comprehending neural information processing.

Purpose of the Study:

  • To review recent advancements in understanding retrograde signaling at developing central synapses.
  • To highlight the different forms and roles of retrograde signals in synaptic function.
  • To emphasize the significance of activity-dependent retrograde factors.

Main Methods:

  • Literature review of recent progress in retrograde signaling research.
  • Analysis of different types of retrograde signaling molecules (membrane-permeant, membrane-bound, secreted).
  • Examination of the role of activity-dependent synaptic plasticity (LTP/LTD) in retrograde signaling.

Main Results:

  • Three forms of retrograde signals (membrane-permeant, membrane-bound, secreted) are implicated in synaptic development and maturation.
  • Both constitutive and activity-dependent retrograde signals exist.
  • Activity-dependent retrograde factors, associated with long-term potentiation and long-term depression, are particularly noteworthy.

Conclusions:

  • Retrograde signaling is a fundamental mechanism in the nervous system.
  • Activity-dependent retrograde signals can modify neuronal excitability and synaptic transmission.
  • These modifications are directly relevant to how the nervous system processes and stores information.

Related Experiment Videos