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[Role of apoptosis in age-related pathologies]
1Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, ul. Kommunisticheskaya 28, Syktyvkar, 167982 Russia.
Ontogenez
|September 28, 2001
Abstract:
A review of recent data concerning the apoptotic death of cells during senescence at the organismic level. The data analyzed suggest interrelations between apoptosis deregulation and some age-related pathologies and senescent phenotypes. Genetic aspects and possible mechanisms of age-related changes in the program of apoptosis are considered. It has been proposed that age-related deregulation of apoptosis is a mechanism of senescence.