Related Experiment Video
Updated: Jan 8, 2026
08:52
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
4.0K
[Biomarkers of aging mechanisms]
1Institute of Longevity with Clinic of Rehabilitation and Preventive Medicine - Petrovsky National Research Centre of Surgery, Moscow, Russia.
Voprosy Kurortologii, Fizioterapii, I Lechebnoi Fizicheskoi Kultury
|December 12, 2025
Summary
This study presents a system of 30+ biomarkers for assessing aging mechanisms and guiding longevity medicine. It provides reference and target values for personalized aging rate evaluation and intervention.
Area of Science:
- Gerontology and Longevity Medicine
- Biomarker Discovery and Validation
- Molecular and Cellular Biology of Aging
Background:
- Aging is a complex process driven by multiple interconnected mechanisms.
- Current knowledge on aging biomarkers requires systematization for practical clinical application.
- Longevity medicine aims to slow aging and extend healthspan through personalized interventions.
Purpose of the Study:
- To consolidate and systematize current knowledge on biomarkers of fundamental aging mechanisms.
- To establish reference and target values for these biomarkers for use in longevity medicine.
- To develop a comprehensive biomarker panel for personalized aging assessment.
Main Methods:
- Systematic analysis of scientific literature on 14 key aging mechanisms.
- Inclusion of established and emerging aging hallmarks such as genomic instability, telomere shortening, and epigenetic alterations.
- Focus on biomarkers related to cellular senescence, mitochondrial dysfunction, and intercellular communication.
Main Results:
- A comprehensive system of over 30 biomarkers with detailed reference and target values has been developed.
- Key biomarkers identified include urinary 8-OHdG, leukocyte telomere length, N7-methylguanine, and markers of autophagy (p62, Beclin-1).
- Other significant biomarkers encompass HOMA-IR, IGF-1, mitochondrial markers, senescence-associated β-galactosidase, inflammatory cytokines, microbiome markers, and circadian biomarkers.
Conclusions:
- The developed biomarker panel offers a scientifically validated approach for personalized aging rate assessment.
- This panel supports the correction of age-associated changes and facilitates personalized longevity strategies.
- Regular monitoring (every 3-6 months) is recommended for effective interpretation of biomarker dynamics and treatment efficacy.
Keywords:
aging biomarkersautophagybiological agecellular senescencecircadian rhythmsepigeneticsextracellular matrixgenomic instabilityinflammationintercellular communicationlongevity medicinemicrobiomemitochondrial dysfunctionoxidative stresspreventive medicineproteostasissenescencestem cellstelomeres
Related Concept Videos
01:26Aging
566
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
566
01:19The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
175
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
175
01:37Mitochondria
19.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.5K
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
181
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
181
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K