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Potential dietary geroprotectors and their impact on key mechanisms of aging

Alexey Moskalev1, Oksana Veselova2

  • 1Longevity Institute of Petrovsky National Research Center of Surgery, Moscow, Russia. amoskalev@med.ru.

Biogerontology
|November 20, 2025
PubMed

Insights

Natural compounds found in food can slow aging processes by targeting key molecular and cellular damage mechanisms. This review explores these geroprotectors and their role in promoting healthy longevity through diet.

Area of Science:

  • Gerontology
  • Nutritional Science
  • Molecular Biology

Background:

  • Aging is characterized by accumulating molecular and cellular damage, increasing disease risk.
  • Natural low-molecular-weight geroprotectors from plants and food can modulate aging mechanisms.
  • Understanding these compounds is crucial for developing interventions against age-related decline.

Purpose of the Study:

  • To analyze sixteen fundamental aging mechanisms.
  • To identify food-derived compounds with potential to slow age-related changes.
  • To explore the molecular and cellular actions of these natural geroprotectors.

Main Methods:

  • Literature review of current scientific data on aging mechanisms.
  • Analysis of compounds from food sources with geroprotective properties.
  • Examination of molecular and cellular mechanisms of action.

Main Results:

  • Sixteen fundamental aging mechanisms were analyzed.
  • Various natural compounds from food sources show potential in slowing aging.
  • The availability and mechanisms of these compounds in common foods were detailed.

Conclusions:

  • Natural nutrients interact with fundamental aging processes.
  • Dietary strategies hold promise for promoting healthy longevity.
  • Further research can leverage these findings for anti-aging interventions.
Keywords:
Dietary compoundsGeroprotectorsHealthspanLongevityMolecular mechanisms

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