Related Experiment Video

Updated: Oct 4, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

EEG bispectral index and hypnotic component of anaesthesia induced by sevoflurane: comparison between children and

C S Degoute1, C Macabeo, C Dubreuil

  • 1Department of Anaesthesiology and Intensive Care, Centre Hospitalo-Universitaire Lyon-Sud, France.

British Journal of Anaesthesia
|September 28, 2001
PubMed

Insights

The bispectral index (BIS) effectively monitors the hypnotic component of sevoflurane anesthesia in both children and adults. This study confirms BIS

Area of Science:

  • Anesthesiology
  • Neurophysiology

Background:

  • Monitoring anesthetic depth is crucial for patient safety.
  • The bispectral index (BIS) is a common tool for assessing hypnotic state during anesthesia.
  • Sevoflurane is a widely used inhalational anesthetic agent.

Purpose of the Study:

  • To evaluate the correlation between the electroencephalographic bispectral index (BIS) and the hypnotic component of anesthesia (CA) induced by sevoflurane.
  • To compare BIS and CA at loss of consciousness (LOC) and recovery of consciousness (ROC) in pediatric and adult patients.
  • To determine if age influences the BIS-CA relationship during sevoflurane anesthesia.

Main Methods:

  • Prospective study design.
  • Inclusion of 27 children and 27 adult patients undergoing sevoflurane anesthesia.
  • Measurement and comparison of BIS and CA at LOC and ROC.

Main Results:

  • BIS significantly decreased at LOC and increased at ROC in both children and adults, with no significant intergroup differences.
  • Strong negative correlations were observed between BIS and CA at both LOC (children: -0.761, adults: -0.911) and ROC (children: -0.876, adults: -0.837).
  • BIS values at ROC were comparable to those at LOC within each group.

Conclusions:

  • The bispectral index (BIS) demonstrates a strong correlation with the hypnotic component of sevoflurane anesthesia in both pediatric and adult populations.
  • BIS can be reliably used to monitor anesthetic depth induced by sevoflurane across different age groups.
  • These findings support the utility of BIS in optimizing sevoflurane administration and ensuring adequate hypnosis during general anesthesia.

More Related Videos

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation06:33

Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation

Published on: January 5, 2014

Related Concept Videos

Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.