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Amlodipine: effective for treatment of mild to moderate essential hypertension and left ventricular hypertrophy

I F Islim1, R D Watson, H N Ihenacho

  • 1University Department of Cardiovascular Medicine, City Hospital NHS Trust, Birmingham, UK.

Cardiology
|September 28, 2001
PubMed

Insights

This study shows that amlodipine, a calcium antagonist, effectively lowers blood pressure in patients with essential hypertension and left ventricular hypertrophy (LVH). Treatment with amlodipine also led to significant improvements in left ventricular mass and diastolic function.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Research

Background:

  • Essential hypertension frequently coexists with left ventricular hypertrophy (LVH).
  • LVH is a significant risk factor for cardiovascular events.
  • Long-acting calcium antagonists are a common treatment for hypertension.

Purpose of the Study:

  • To investigate the efficacy of amlodipine in patients with essential hypertension and LVH.
  • To assess the impact of amlodipine on blood pressure, left ventricular mass, and diastolic function.

Main Methods:

  • A 20-week, open-label, uncontrolled clinical investigation.
  • 33 patients with essential hypertension and LVH received daily doses of amlodipine (5-10 mg/day).
  • Evaluated changes in sitting blood pressure, heart rate, left ventricular mass index, and left ventricular diastolic filling (E/A ratio).

Main Results:

  • Amlodipine significantly reduced systolic (-13.0%) and diastolic (-13.8%) blood pressures (p=0.0001).
  • Significant regression in left ventricular mass index was observed (p<0.01).
  • Total peripheral resistance decreased, and left ventricular diastolic filling improved (E/A ratio increased, p=0.038).

Conclusions:

  • Amlodipine provides a consistent antihypertensive effect in patients with essential hypertension and LVH.
  • Short-term amlodipine treatment is associated with significant regression of left ventricular hypertrophy.
  • Amlodipine improves cardiac structure and function in hypertensive patients with LVH.

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