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Targeting protein kinases for tumor therapy

C Sachsenmaier1

  • 1KTB Tumorforschungsgesellschaft mbH, Klinik für Tumorbiologie, Freiburg, Germany. sachsenm@tumorbio.uni-freiburg.de

Onkologie
|September 28, 2001
PubMed

Insights

Protein kinases regulate cell functions and are key in cancer development. This review covers their role in cancer and ongoing clinical trials targeting them for tumor therapy.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Phosphorylation is a crucial post-translational modification regulating vital cellular processes.
  • Protein and lipid kinases, along with phosphatases, are implicated in human diseases, particularly cancer.

Purpose of the Study:

  • To review the involvement of protein kinases in human cancer.
  • To provide an updated list of clinical trials targeting protein kinases for cancer therapy.

Main Methods:

  • Literature review focusing on protein kinases in cancer.
  • Compilation of ongoing clinical trials and therapeutic strategies.

Main Results:

  • Protein kinases play a significant role in the pathogenesis of various human cancers.
  • Numerous clinical trials are investigating protein kinase inhibitors as anti-cancer agents.

Conclusions:

  • Targeting protein kinases represents a promising therapeutic avenue for cancer treatment.
  • Further research into protein kinase inhibitors is essential for advancing cancer therapy.

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