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Haploidentical transplantation. Importance of histocompatibility testing and chimerism studies in allogeneic bone
1East Carolina University School of Medicine, Department of Pathology, Brody Building Room 7S-10, Greenville, NC 27858, USA. rebellatol@mail.ecu.edu
Abstract:
The transplantation of hematopoietic stem cells is sometimes the only treatment option for certain types of malignancies and hematological disorders. The best way to ensure a positive outcome from this type of procedure is to secure an identical human lymphocyte antigen-matched donor or use an autologous graft. This article reviews the indications for transplantation, the recipient and donor selection process, and posttransplant follow-up. The advantages of using haploidentical donors and the typing process also will be discussed.