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Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

[Contraction-relaxation dynamics and mechanical restitution in the developing myocardium of the chick embryo]

P B Tsyv'ian1, V S Markhasin, O E Solov'eva

  • 1Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Acad. Sci., 620016 Ekaterinburg, Sladskoy Proezd, 6, Russia.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|September 29, 2001
PubMed

Insights

Cardiac muscle contraction and relaxation differ between embryonic and posthatched chicks. A sarcolemmal calcium pool and Na-Ca exchange regulate these processes, impacting mechanical restitution.

Area of Science:

  • Cardiovascular Physiology
  • Developmental Biology
  • Cellular Electrophysiology

Context:

  • Investigating the developmental changes in cardiac muscle function.
  • Understanding the role of calcium handling in myocardial contractility.
  • Examining mechanical restitution and its regulation.

Purpose:

  • To compare contraction-relaxation parameters and mechanical restitution in embryonic and posthatched chick ventricular preparations.
  • To elucidate the influence of ryanodine and low sodium on these parameters.
  • To determine the contribution of a sarcolemmal calcium pool and Na-Ca exchange.

Summary:

  • Ryanodine affected relaxation rates differently in embryonic versus posthatched chicks, suppressing potentiation and mechanical restitution in both.
  • Low sodium superfusion impaired relaxation and reduced rest potentiation across all developmental stages.
  • These findings support the presence of a sarcolemmal calcium pool regulating twitch dynamics and calcium efflux via Na-Ca exchange.

Impact:

  • Provides insights into the developmental maturation of cardiac excitation-contraction coupling.
  • Highlights the distinct roles of intracellular and sarcolemmal calcium pools during development.
  • Offers a foundation for understanding age-related alterations in cardiac contractility and calcium handling.

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