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Self-healing generalized infantile myofibromatosis with elevated urinary bFGF
C Léauté-Labrèze1, M P Labarthe, J F Blanc
1Department of Pediatric Dermatology, Pellegrin Hospital, Bordeaux, France.
Pediatric Dermatology
|September 29, 2001
Summary
Generalized infantile myofibromatosis, a rare condition, can have a favorable outcome even with systemic involvement. Elevated urinary basic fibroblast growth factor (bFGF) suggests its role in the disease pathogenesis.
Area of Science:
- Oncology
- Pediatrics
- Pathology
Background:
- Generalized infantile myofibromatosis is a rare neoplastic disorder characterized by multiple myofibromas.
- Systemic involvement can occur, posing significant clinical challenges.
Observation:
- A case of generalized infantile myofibromatosis with widespread lesions is presented.
- The patient experienced a favorable clinical outcome despite extensive disease.
Findings:
- Elevated urinary levels of basic fibroblast growth factor (bFGF) were observed during the active disease phase.
- This finding suggests that angiogenic stimulation, mediated by bFGF, may play a crucial role in the pathogenesis of infantile myofibromatosis.
Implications:
- Understanding the role of bFGF in infantile myofibromatosis could lead to targeted therapies.
- This case highlights the importance of monitoring angiogenic factors in pediatric tumors.