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Updated: Jul 28, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Low molecular weight heparin therapy for percutaneous coronary intervention: a practice in evolution
1Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.
Journal of Thrombosis and Thrombolysis
|September 29, 2001
Summary
Unfractionated heparin (UFH) poses risks during percutaneous coronary intervention (PCI). Low molecular weight heparin (LMWH) offers a safer, more predictable alternative for patients with acute coronary syndromes undergoing PCI.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Unfractionated heparin (UFH) is the standard antithrombotic for percutaneous coronary intervention (PCI).
- UFH has limitations: unpredictable dosing, frequent monitoring needs, and rebound hypercoagulability.
- Low molecular weight heparin (LMWH) shows promise as an alternative with improved predictability and safety.
Purpose of the Study:
- To review the rationale and existing data for using LMWH in PCI.
- To present preliminary guidelines for LMWH use in acute coronary syndrome (ACS) patients transitioning to PCI.
Main Methods:
- Literature review of studies on LMWH in PCI.
- Analysis of clinical data regarding LMWH efficacy and safety.
- Development of preliminary clinical guidelines.
Main Results:
- LMWH demonstrates a predictable dose response and superior efficacy compared to UFH.
- LMWH offers potential for improved clinical safety in PCI procedures.
- Existing data supports LMWH use in ACS patients prior to angiography.
Conclusions:
- LMWH is a viable and potentially superior alternative to UFH for anticoagulation during PCI.
- Guidelines are proposed for the transition to LMWH in ACS patients undergoing invasive procedures.
- Further research may solidify LMWH's role in interventional cardiology.
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