Related Experiment Videos
DNA-ploidy and mutant p53 overexpression in primary fallopian tube cancer
A.-C. Hellström1, J. Hue, C. Silfverswärd
1Department of Gynaecology and Oncology, Radiumhemmet, and Department of Tumor Pathology, Karolinska Hospital and Institute, Stockholm, Sweden.
Abstract:
Nuclear DNA content and p53 immunoreactivity were determined in 53 cases of primary fallopian tube cancer (PFTC). All tumors showed a distinctly aneuploid DNA distribution pattern, whereas p53 immunoreactivity was observed in 51% of the cases. If the patients were divided into two groups according to survival time, p53 immunoreactivity was present in 40% of the tumors from patients surviving for more than 8 years and in 65% of tumors from patients who died within 2 years. This difference was not statistically significant (P = 0.438). Patient survival was significantly correlated to the clinical stage (FIGO) (P = 0.0009).