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Activation of CD14 on circulating monocytes in patients with acute coronary syndrome

W H Lee1, Y Lee, J O Jeong

  • 1Cardiology Division, Samsung Medical Center, Seoul 135-710, South Korea.

International Journal of Cardiology
|October 2, 2001
PubMed

Insights

Inflammation plays a key role in acute coronary syndrome (ACS). Monocyte CD14 expression and T-lymphocyte activation markers were elevated in ACS patients, decreasing with treatment, indicating their value in assessing disease status.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biochemistry

Background:

  • Inflammation is increasingly recognized as a critical factor in the acute phase of coronary artery diseases.
  • Understanding inflammatory markers can provide insights into disease mechanisms and progression.

Purpose of the Study:

  • To investigate the activation status of inflammatory cells in patients with acute coronary syndrome (ACS).
  • To evaluate specific markers, CD14 expression on monocytes and HLA-DR on T-lymphocytes, as indicators of inflammation in ACS.

Main Methods:

  • Flow cytometry was used to analyze inflammatory cell activation in 38 ACS patients, 14 stable angina patients, and 19 controls.
  • Monocyte activation was assessed by CD14 expression, and T-lymphocyte activation by HLA-DR positivity.
  • Tumor necrosis factor-alpha secretion was measured after lipopolysaccharide stimulation.

Main Results:

  • ACS patients exhibited significantly higher CD14 expression on monocytes and HLA-DR positive T-lymphocytes compared to controls and stable angina patients.
  • A 2.4-fold higher secretion of tumor necrosis factor-alpha was observed in ACS patients.
  • Following medical treatment, significant reductions in both CD14 expression and HLA-DR positive T-lymphocytes were noted in ACS patients.

Conclusions:

  • Elevated monocytic CD14 expression in ACS patients indicates activated monocytes and hyper-responsiveness.
  • CD14 expression levels decrease with treatment, confirming its utility in reflecting monocyte activation during acute coronary artery disease.
  • These markers are valuable for assessing inflammatory status in ACS.
Abstract

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