Jove
Visualize
Contact Us

Related Experiment Videos

Apical tuft input efficacy in layer 5 pyramidal cells from rat visual cortex.

P A Rhodes1, R R Llinás

  • 1Department of Physiology and Neuroscience, New York University Medical School, 550 1st Avenue, New York, NY 10016, USA. rhodesp@mindspring.com

The Journal of Physiology
|October 2, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tau pathology-mediated presynaptic dysfunction.

Neuroscience·2016
Same author

Scanning electrochemical microscopy as a novel proximity sensor for atraumatic cochlear implant insertion.

IEEE transactions on bio-medical engineering·2014
Same author

Evidence for an all-or-none perceptual response: single-trial analyses of magnetoencephalography signals indicate an abrupt transition between visual perception and its absence.

Neuroscience·2011
Same author

Abnormal thalamocortical activity in patients with Complex Regional Pain Syndrome (CRPS) type I.

Pain·2010
Same author

Inferior olive oscillation as the temporal basis for motricity and oscillatory reset as the basis for motor error correction.

Neuroscience·2009
Same author

Magnetic sources of the M50 response are localized to frontal cortex.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2007
Same journal

Who are you, ketamine? Good, evil, or dose- and context-dependent?

The Journal of physiology·2026
Same journal

Nuances in explaining the blunted erythropoietic response at altitude following recombinant human erythropoietin treatment at sea level.

The Journal of physiology·2026
Same journal

Sex-dependent responses to glucagon agonist therapies in obesity: Mechanistic insights and broader pharmacological implications.

The Journal of physiology·2026
Same journal

Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia.

The Journal of physiology·2026
Same journal

Protein kinase Cδ and pharmacomechanical coupling: Re-envisioning cerebral vascular control.

The Journal of physiology·2026
Same journal

Improved subjective sleep quality in older adults by enhancing the GABAergic system in the sensorimotor cortex.

The Journal of physiology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Synaptic input to the apical tuft of layer 5 pyramidal cells effectively triggers firing due to cell geometry, not excitability. Background noise surprisingly enhances this tuft input efficacy.

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Layer 5 pyramidal cells are crucial for cortical processing.
  • Understanding synaptic integration in dendrites is key to neuronal function.

Purpose of the Study:

  • Investigate synaptic input integration in layer 5 pyramidal cells.
  • Characterize regenerative responses under varying background synaptic conditions.

Main Methods:

  • Compartment model simulations of a layer 5 pyramidal cell.
  • Compared responses with and without background synaptic conductance.
  • Analyzed dendritic active currents and channel distributions.

Main Results:

  • Apical tuft input effectively elicits somatic firing, even without tuft excitability.

Related Experiment Videos

  • Cellular geometry, specifically the tuft-trunk junction, drives this efficacy.
  • Background synaptic conductance paradoxically enhances tuft input effectiveness by limiting voltage spread.

    • Conclusions:

    • Apical tuft synaptic input is unexpectedly potent for triggering layer 5 cell firing in vivo.
    • Efficacy relies on dendritic geometry and apical trunk propagation, not tuft excitability.
    • Modulation of apical trunk currents could control tuft input efficacy.