Related Experiment Video

Updated: Aug 17, 2026

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
10:38

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

Published on: September 9, 2015

[Clinical features in six patients with liver abscess caused by Streptococcus milleri]

R Tomiyama1, M Yamashiro, H Sakugawa

  • 1Department of Internal Medicine, Okinawa Prefectural Miyako Hospital.

Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of Gastro-Enterology
|October 3, 2001
PubMed

Insights

Streptococcus milleri (S. milleri) caused 15% of pyogenic liver abscesses in this study. Antibiotic selection for liver abscesses should consider S. milleri and intraoral anaerobes due to similar clinical presentations.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Hepatology

Context:

  • Pyogenic liver abscess (PLA) is a serious intra-abdominal infection.
  • The spectrum of causative pathogens in PLA is diverse.
  • Streptococcus milleri group (SMG) bacteria are increasingly recognized as pathogens in various infections.

Purpose:

  • To investigate the clinical features and outcomes of pyogenic liver abscesses caused by Streptococcus milleri (S. milleri).
  • To compare the clinical presentation of S. milleri liver abscesses with those caused by other bacteria.
  • To inform antibiotic selection strategies for liver abscess treatment.

Summary:

  • Six out of 39 (15%) patients with pyogenic liver abscess were infected by S. milleri.
  • Patients infected with S. milleri were predominantly male (5/6), with a mean age of 61 years, and often had underlying illnesses (5/6).
  • Clinical features, including fever and abdominal pain, did not significantly differ between S. milleri and other bacterial liver abscesses. Mixed infections, including intraoral anaerobes like Fusobacterium, were noted in three patients.

Impact:

  • Highlights the importance of considering S. milleri and associated intraoral anaerobes in the differential diagnosis of pyogenic liver abscess.
  • Suggests that current antibiotic regimens for liver abscess may need to be broadened to ensure adequate coverage for S. milleri.
  • Emphasizes the need for further research into the specific role and optimal management of S. milleri in liver abscess cases.

More Related Videos

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes08:34

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice14:10

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...