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Fluorescence nanotomography using resonance energy transfer: demonstration with a protein-sugar complex
O J Rolinski1, Birch DJS, L J McCartney
1Department of Physics and Applied Physics, University of Strathclyde, Glasgow, UK.
Physics in Medicine and Biology
|October 3, 2001
Abstract:
A new approach to structural sensing, fluorescence resonance energy transfer nanotomography, which interprets fluorescence decay measurement in terms of site density analysis of molecular distributions, has been applied to a glucose sensor based on competitive binding with malachite green labelled dextran to the sugar binding protein concanavalin A labelled with allophycocyanin. Opportunities for structural sensing in clinical medicine are highlighted.