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Decrease in myelin content of rabbit sciatic nerve with aging and diabetes.

N Spritz, H Singh, B Marinan

    Diabetes
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Diabetic neuropathy in rabbits shows decreased peripheral nerve myelin starting at six months. Aging also reduces myelin, with changes in cholesterol and glycolipid content in sciatic nerves.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Diabetology

    Background:

    • Peripheral nerve myelin quantification traditionally relies on histologic methods.
    • Direct measurement of myelin content offers a more precise approach.

    Purpose of the Study:

    • To directly quantify peripheral nerve myelin content in rabbits.
    • To investigate the impact of diabetes and aging on myelin quantity and composition.

    Main Methods:

    • Quantitative isolation of myelin from rabbit sciatic nerves.
    • Analysis of myelin composition in young and old rabbits, with and without diabetes.

    Main Results:

    • Myelin content decreased starting at nine months in normal rabbits and at six months in diabetic rabbits.

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  • Myelin composition was similar across species but affected by aging, showing decreased cholesterol and increased glycolipid.

    • Conclusions:

    • Diabetes accelerates myelin reduction in peripheral nerves.
    • Aging significantly alters myelin composition, independent of diabetes.